GLORY is a tool for predicting metabolites that can be formed in humans by enzymes belonging to the cytochrome P450 (CYP) enzyme family.
Sites of metabolism (SoM) are predicted with FAME 2, then combined with CYP-mediated reactions from the reaction rule set that was created specifically for GLORY. The structures of the predicted metabolites are provided in an sdf file.
For more information, see the About page.
If you are using GLORY for your research, please cite all of the following publications:
de Bruyn Kops, C.; Stork, C.; Šícho, M.; Kochev, N.; Svozil, D.; Jeliazkova, N.; Kirchmair, J. GLORY: Generator of the Structures of Likely Cytochrome P450 Metabolites Based on Predicted Sites of Metabolism. Front. Chem. 2019, 7:402.
Stork, C.; Embruch, G.; Šícho, M.; de Bruyn Kops, C.; Chen, Y.;
Svozil, D.; Kirchmair, J. NERDD: a web portal providing access to in
silico tools for drug discovery. Bioinformatics